There currently are a variety of options to travel by night train or night bus from Prague (Czech Republic) to Brussels (Belgium), taking between approximately 12 and 18 hours: Namely the ES 452 and the BUS Praha - Londýn. These lines are operated by European Sleeper and Regiojet.

Next offers

European Sleeper is a young Dutch startup connecting several European cities in Belgium, the Netherlands, Germany and the Czech Republic with their "Good Night Train". The sleeper cars offer comfortable and lockable compartments for one, two or three persons, each equipped with a washbasin. The service includes bedding, towels, toiletries and breakfast. A wake-up service is available. The couchette cars come in two variants: standard (6 people) and comfort (5 people, air-conditioned). Both include bedding, blankets and pillows. Comfort compartments can be booked as private or women-only compartments. The compartments can be locked from the inside. The seating cars offer, as the most affordable travel option, 6-person compartments with guaranteed seat reservations. Breakfast can be booked for an additional fee, drinks and snacks are available on board.

Regiojet operates both night trains and night buses across Europe, providing various travel options. Regiojet night trains offer a range of cabin options, from standard reclining seats in open compartments to private couchette cabins designed for one to four travelers, complete with bedding and duvets for a restful journey. Wifi is available and breakfast and coffee are served for free. Regiojet night buses feature ergonomic seating that can recline for comfort, with generous legroom and amenities such as USB charging ports, free WiFi, personal entertainment screens, and complimentary refreshments available during the journey. There is also a toilet on the bus.

For the next 7 dates with connections, the cheapest offer starts at 40 EUR. Check our connection pages below for all availabilities!

Next available offers

Fri, 09.05.2025

from 50 EUR

Sun, 11.05.2025

from 150 EUR

Tue, 13.05.2025

from 40 EUR

Thu, 15.05.2025

from 60 EUR

Fri, 16.05.2025

from 40 EUR

Sun, 18.05.2025

from 90 EUR

Tue, 20.05.2025

from 40 EUR